Beilstein J. Org. Chem.2021,17, 1360–1373, doi:10.3762/bjoc.17.95
degradation of antiviral RNA molecules. The present work demonstrates that VLPs (virus-like particles) allow efficient delivery of dsRNAi as antiviraltherapy in shrimp. In particular, VLPs derived from a virus that infects plants, such as cowpea chlorotic mottle virus (CCMV), in which the capsid protein (CP
applied to pathogen control in shrimp and also other organisms, widening the application window in nanomedicine.
Keywords: antiviraltherapy; CCMV; oral administration; P. vannamei; plant VLPs; RNAi; VP28; white spot syndrome virus; Introduction
The white spot syndrome virus (WSSV) is recognized as one
with the antiviraltherapy was evaluated through the survival and mean lethal time (LT50) [52]. A Log-Rank (Mantel–Cox) test was used to analyze the Kaplan–Meier survival curves generated with the GraphPad Prism version 5.01 software (San Diego California USA). In all cases, a value of p < 0.05 was
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Graphical Abstract
Figure 1:
Analysis of the VLP-dsRNAvp28 assembly by electrophoresis mobility shift assay (EMSA) in a 1% nativ...